Back to Afia

F41.8 — ICD-10 code for depression with anxiety

Mixed anxiety and depressive disorder is F41.8, and it is billable as written. Two things make this one hard to find. It sits under a heading that does not mention it — F41.8 is titled other specified anxiety disorders, with mixed anxiety and depressive disorder listed as an inclusion term. And the obvious-looking alternative is wrong: F41.3 is other mixed anxiety disorders, which mixes anxiety with something other than depression. Below: when F41.8 is right, when to code both conditions separately instead, and the CPT pairings.

This page is billing and administrative reference. It describes what a code means and whether it can be submitted. It is not clinical advice and does not tell anyone what to diagnose.

F41.8 or F41.3?

The names invite the mistake. ICD-10-CM lists three inclusion terms under F41.8:

F41.3 carries no inclusion terms at all and is titled other mixed anxiety disorders — anxiety mixed with a condition that is not depression. If the picture is anxiety plus depression, F41.8 is the code.

The F41 family

CodeTitleBillable?
F41Other anxiety disorders (category header)No
F41.0Panic disorder [episodic paroxysmal anxiety]Yes
F41.1Generalized anxiety disorderYes
F41.3Other mixed anxiety disordersYes
F41.8Other specified anxiety disordersYes
F41.9Anxiety disorder, unspecifiedYes

F41.2 is absent from ICD-10-CM: the family runs .0, .1, .3, .8, .9.

When to use it, and when to code both separately

F41.8 describes a presentation where anxiety and depressive symptoms are both present and neither is severe enough to stand as a diagnosis in its own right. That is what the inclusion term “anxiety depression (mild or not persistent)” is signalling.

Where the record does support both diagnoses independently — a major depressive episode and generalized anxiety disorder, each meeting criteria — the accurate coding is both codes, not F41.8: for example F33.1 alongside F41.1. Collapsing two established diagnoses into F41.8 understates the record, and it is the weaker choice if the claim is reviewed.

There is a second boundary worth knowing. Persistent anxiety depression is F34.1, in the persistent mood disorder family, and ICD-10-CM records this as an Excludes2 against F41.8. Persistence is what decides between them: F41.8 is for the mild or non-persistent picture, F34.1 for one that has continued for years.

DSM-5 crosswalk

This is the part that causes the confusion, and it is worth being plain about. DSM-5 has no mixed anxiety and depressive disorder. The diagnosis was proposed for DSM-5 and was not included in the final manual, so a clinician assessing strictly against DSM-5 criteria never arrives at it.

What DSM-5 offers instead is the with anxious distress specifier on a depressive or bipolar episode — which does not change the ICD-10-CM code. So the DSM-5 route for a depressed patient with prominent anxiety is an F32 or F33 code with that specifier documented, while the ICD-10-CM route offers F41.8 as a code in its own right.

Both are defensible. What causes problems is using F41.8 as shorthand for “depressed and anxious” when the record actually establishes a major depressive episode — the specific code is more accurate and better supported.

CPT codes billed with mixed anxiety and depression

CPTServiceTime
90791Psychiatric diagnostic evaluation (no medical services)—
90832Individual psychotherapy16–37 minutes
90834Individual psychotherapy38–52 minutes
90837Individual psychotherapy53 minutes or more
90847Family psychotherapy, patient present50 minutes typical
90853Group psychotherapy—

A 50-minute session is 90834, not 90837 — 90837 begins at 53 minutes. CMS also sets a floor: psychotherapy under 16 minutes is not reported with these codes at all.

Check it live

Afia is free and answers these by voice or chat — find a code from a condition name, confirm whether a code is billable, validate a whole list at once, or check a session length against a CPT time band. No sign-up.

Frequently asked questions

Is F41.8 billable?

Yes. F41.8 is a specific code and valid for submission. F41 on its own is a category header and is not.

What is the ICD-10 code for depression with anxiety?

F41.8. ICD-10-CM lists mixed anxiety and depressive disorder as an inclusion term under it, along with anxiety depression that is mild or not persistent.

What is the difference between F41.8 and F41.3?

F41.3 is other mixed anxiety disorders — anxiety mixed with something that is not depression. Mixed anxiety and depressive disorder is an inclusion term under F41.8, not F41.3.

Should I code F41.8 or both F32 and F41.1?

Code both separately when the record supports each diagnosis independently. F41.8 is for a picture where anxiety and depressive symptoms are both present but neither stands alone as a diagnosis.

Does DSM-5 have mixed anxiety and depressive disorder?

No. It was proposed for DSM-5 and not included. DSM-5 offers a with anxious distress specifier on a depressive episode instead, which does not change the ICD-10-CM code.

Check a code with Afia — free

Codes on this page were verified against the CMS ICD-10-CM code sets for FY2026 and FY2027 (FY2027 effective 1 October 2026). Last reviewed 19 September 2026. Verify against the current official code set before submitting.